Clinical Trials

Fueling the Debate on Statin Use in Older Adults

The use of statins for primary cardiovascular disease prevention in adults over age 75 is clouded in uncertainty. A recent study in the Journal of the American Geriatrics Society found that statins may significantly lower mortality risk in older adults. That only underscores the need for a large-scale, prospective, randomized clinical trial, researchers say.


Exercise Study Suggests New Approach to Slowing Parkinson’s

High-intensity treadmill exercise can be safely prescribed for patients with de novo Parkinson’s disease (PD) and may slow progression of some of the disease’s effects, according to a phase 2 clinical trial, the results of which were published in JAMA Neurology.


Testosterone Therapy for Older Hypogonadal Men: The Debate Continues

Long-term testosterone therapy improves urinary and sexual function in hypogonadal men, according to a recent study. Other recent findings, however, continue to fuel debate as to whether the potential benefits of the treatment outweigh the risks.


Bunches of Promise: Study Shows Grape Compounds May Prevent Colorectal Cancer

A combination of grape seed extract (GSE) and the grape compound resveratrol suppresses colon cancer stem cells with efficacy similar to that of a chemopreventive drug, but without the latter’s adverse effects, according to Pennsylvania State University researchers. They believe their findings could open the door to novel therapies to prevent colorectal cancer.


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Extended Antibiotic Use May Boost Risk of Colorectal Cancer Precursor

Long use of antibiotics is associated with higher risk of colorectal adenoma, according to an observational study in Gut. Adenomas are precursors for most colorectal cancers.

A multi-institutional team of...


Link between ALS, Schizophrenia May Spur New Paths of Research

Amyotrophic lateral sclerosis and schizophrenia share genetic origins, according to recent research published in Nature Communications. That finding has the potential to change how neurological and psychiatric diseases are studied and furthers hopes of curing both conditions.


Tobacco Cessation Eases Depression Symptoms in Smokers, Research Shows

Smokers living with depression who quit the habit by using certain smoking cessation services could gain significantly improved mental health, according to a recent study in Annals of Behavioral Medicine.


A Breath of Foul Air: Pollution and Pediatric Diabetes Risk

Research at the University of Southern California has uncovered a link between air pollution and elevated risk of Type 2 diabetes among overweight Latino children.


Empagliflozin: A Transformative Approach to Diabetes?

A major trial demonstrated the glucose-lowering drug empagliflozin reduces cardiovascular morbidity and mortality in individuals with Type 2 diabetes and existing cardiovascular disease. Clinicians and researchers discuss how it does so and who is most likely to benefit.


Beta-amyloid Research Ignites Treatment Hopes for Alzheimer’s Disease

Results of a phase 1b clinical trial published in Nature reveal scientists may be one step closer to finding a treatment that safely impedes the biological progression of Alzheimer’s disease.